Discovery and development of antiviral drugs

Preclinical development of antiviral drugs.

The early preclinical development of an antiviral agent is accomplished essentially in two stages. The first stage consists of gathering data to estimate the potential therapeutic index of the agent. This process includes testing for antiviral activity and for cytotoxicity in vitro and performing preliminary pharmacokinetic and toxicology studies in vivo. The second stage consists of carrying o...

Targeting Norovirus: Strategies for the Discovery of New Antiviral Drugs

Antiviral drug discovery: broad-spectrum drugs from nature.

Covering: up to April 2014. The development of drugs with broad-spectrum antiviral activities is a long pursued goal in drug discovery. It has been shown that blocking co-opted host-factors abrogates the replication of many viruses, yet the development of such host-targeting drugs has been met with scepticism mainly due to toxicity issues and poor translation to in vivo models. With the advent ...

Peptides as Drugs: Discovery and Development

Discovery and Development of a Style-Making Figure

Styles in the normal course of historical development change and evolve, and in the process of this movement and change, some poets play a vital role. These poets try to be inventive in order to escape banality and repeated and shallow literary traditions, and by creating a rift between themselves and former traditions they introduce new elements.  These artists either create new figures o...